Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | CDC25B | P30305 | 1/20 | 0.45 |
| ▸ | CCKBR | P32239 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PLG | P00747 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | FPGS | Q05932 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7385051 | 0.93 | PTPN1 (0.46) | PTPN1ALOX5NPC1MAPTPTPN2 | |
| SCHEMBL7420467 | 0.87 | PTPN1 (0.45) | PTPN1ALOX5NPC1MAPTPTPN2 | |
| SCHEMBL7678439 | 0.87 | ADAMTS4 (0.48) | PTPN1NPC1MAPTCCKBRDHFR | |
| SCHEMBL7696969 | 0.87 | PTPN1 (0.56) | PTPN1ALOX5NPC1MAPTPTPN2 | |
| SCHEMBL7661370 | 0.84 | CCKBR (0.44) | MAPTCCKBRCTSLCTSSCTSB | |
| SCHEMBL7659961 | 0.82 | MEN1 (0.52) | NPC1MAPTCCKBRMEN1RAB9A | |
| SCHEMBL7694848 | 0.81 | PTPN1 (0.55) | PTPN1ALOX5NPC1MAPTPTPN2 | |
| SCHEMBL7665000 | 0.78 | ALDH1A1 (0.52) | CCKBRMEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL7666410 | 0.77 | CCKBR (0.42) | NPC1MAPTCCKBRCTSLCTSS | |
| SCHEMBL7702953 | 0.76 | PTPN1 (0.53) | PTPN1NPC1MAPTPTPN2CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436925-B1 | BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |