Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.56 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.52 |
| ▸ | CDC25B | P30305 | 1/20 | 0.52 |
| ▸ | ACE | P12821 | 4/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | CTSK | P43235 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7694848 | 0.92 | PTPN1 (0.55) | PTPN1GPR132PTPN2CDC25BACE | |
| SCHEMBL7664997 | 0.87 | PTPN1 (0.51) | PTPN1PTPN2CDC25BCTSLCTSB | |
| SCHEMBL7702953 | 0.87 | PTPN1 (0.53) | PTPN1GPR132PTPN2CDC25BACE | |
| SCHEMBL7701695 | 0.86 | CA2 (0.52) | PTPN1GPR132PTPN2CDC25BACE | |
| SCHEMBL7694676 | 0.83 | CTSL (0.49) | PTPN1PTPN2CDC25BACECTSL | |
| SCHEMBL7789811 | 0.82 | PIN1 (0.55) | PTPN1GPR132PTPN2CDC25BNPC1 | |
| SCHEMBL7789810 | 0.82 | PIN1 (0.55) | PTPN1GPR132PTPN2CDC25BNPC1 | |
| SCHEMBL1123112 | 0.80 | PTPN1 (0.64) | PTPN1GPR132PTPN2CDC25BCA2 | |
| SCHEMBL7789862 | 0.79 | CAPN1 (0.72) | PTPN1GPR132PTPN2CDC25BRAB9A | |
| SCHEMBL7789863 | 0.79 | CAPN1 (0.72) | PTPN1GPR132PTPN2CDC25BRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436925-B1 | BETTER ABLE TO CROSS MEMBRANES; INHIBITORS OF CYSTEINE PROTEASES LIKE CALPAIN I AND II AND CATHEPSIN B AND L, CAN THUS BE USED TO CONTROL DISEASES ASSOCIATED WITH AN ELEVATED ACTIVITY OF CALPAIN ENZYMES OR CATHEPSIN ENZYMES | ABBOTT LABORATORIES | 2002-08-20 | — | — | US | disclosed |