Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 11/20 | 0.48 |
| ▸ | HTR7 known ✓ | P34969 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | PPARA | Q07869 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL18038518 | 0.91 | SIGMAR1 (0.48) | SIGMAR1DRD2PARP1HTR1AHTR7 | |
| SCHEMBL7664078 | 0.86 | SIGMAR1 (0.62) | SIGMAR1DRD2PARP1HTR1AHTR7 | |
| Fumaric Acid SCHEMBL7658104 | 0.86 | SIGMAR1 (0.53) | SIGMAR1PPARGPPARADRD2PARP1 | |
| Fumaric Acid SCHEMBL7658099 | 0.86 | SIGMAR1 (0.53) | SIGMAR1PPARGPPARADRD2PARP1 | |
| Hydrochloric Acid SCHEMBL7667688 | 0.85 | SIGMAR1 (0.61) | SIGMAR1DRD2PARP1HTR1A | |
| Phosphoric Acid SCHEMBL7658559 | 0.85 | SIGMAR1 (0.55) | SIGMAR1DRD2PARP1HTR1A | |
| Sulfuric Acid SCHEMBL7664307 | 0.85 | SIGMAR1 (0.55) | SIGMAR1PPARGPPARADRD2PARP1 | |
| SCHEMBL7667644 | 0.83 | SIGMAR1 (0.53) | SIGMAR1PPARGPPARADRD2PARP1 | |
| SCHEMBL5846461 | 0.80 | SIGMAR1 (0.44) | SIGMAR1PPARGPPARADRD2PARP1 | |
| SCHEMBL5846061 | 0.78 | SIGMAR1 (0.60) | SIGMAR1DRD2PARP1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355659-B1 | TREATING PSYCHOSIS AND DEMENTIA BY ADMINISTERING | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2002-03-12 | — | — | US | claimed |
| US-6355659-B1 | TREATING PSYCHOSIS AND DEMENTIA BY ADMINISTERING | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2002-03-12 | — | — | US | disclosed |