Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.48 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL7664307 | 0.96 | SIGMAR1 (0.55) | SIGMAR1DRD2HTR1APPARGPPARA | |
| SCHEMBL7664078 | 0.92 | SIGMAR1 (0.62) | SIGMAR1DRD2HTR1AHTR7MEN1 | |
| Hydrochloric Acid SCHEMBL7667688 | 0.90 | SIGMAR1 (0.61) | SIGMAR1DRD2HTR1AMEN1KMT2A | |
| Phosphoric Acid SCHEMBL7658559 | 0.90 | SIGMAR1 (0.55) | SIGMAR1DRD2HTR1AMEN1KMT2A | |
| Fumaric Acid SCHEMBL7658104 | 0.87 | SIGMAR1 (0.53) | SIGMAR1DRD2HTR1APPARGPPARA | |
| Fumaric Acid SCHEMBL7658099 | 0.87 | SIGMAR1 (0.53) | SIGMAR1DRD2HTR1APPARGPPARA | |
| Citric Acid SCHEMBL7665179 | 0.83 | SIGMAR1 (0.48) | SIGMAR1DRD2HTR1APPARGPPARA | |
| SCHEMBL5846061 | 0.80 | SIGMAR1 (0.60) | SIGMAR1DRD2HTR1AMEN1KMT2A | |
| SCHEMBL918431 | 0.77 | SIGMAR1 (0.60) | SIGMAR1DRD2HTR1APARP1 | |
| SCHEMBL5846267 | 0.74 | SIGMAR1 (0.60) | SIGMAR1DRD2HTR1AHTR7PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355659-B1 | TREATING PSYCHOSIS AND DEMENTIA BY ADMINISTERING | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2002-03-12 | — | — | US | claimed |
| US-6355659-B1 | TREATING PSYCHOSIS AND DEMENTIA BY ADMINISTERING | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2002-03-12 | — | — | US | disclosed |