Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.49 |
| ▸ | PPARG known ✓ | P37231 | 4/20 | 0.46 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.53 |
| ▸ | PPARA | Q07869 | 4/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7658099 | 1.00 | SIGMAR1 (0.53) | SIGMAR1DRD2PPARGPPARAPARP1 | |
| SCHEMBL7664078 | 0.91 | SIGMAR1 (0.62) | SIGMAR1DRD2PARP1HTR1A | |
| Hydrochloric Acid SCHEMBL7667688 | 0.90 | SIGMAR1 (0.61) | SIGMAR1DRD2PARP1HTR1A | |
| Sulfuric Acid SCHEMBL7664307 | 0.89 | SIGMAR1 (0.55) | SIGMAR1DRD2PPARGPPARAPARP1 | |
| Phosphoric Acid SCHEMBL7658559 | 0.89 | SIGMAR1 (0.55) | SIGMAR1DRD2PARP1HTR1A | |
| SCHEMBL7667644 | 0.87 | SIGMAR1 (0.53) | SIGMAR1DRD2PPARGPPARAPARP1 | |
| Citric Acid SCHEMBL7665179 | 0.86 | SIGMAR1 (0.48) | SIGMAR1DRD2PPARGPPARAPARP1 | |
| SCHEMBL5846061 | 0.81 | SIGMAR1 (0.60) | SIGMAR1DRD2PARP1HTR1A | |
| Maleic Acid SCHEMBL8092718 | 0.79 | SIGMAR1 (0.83) | SIGMAR1DRD2PPARGPPARAPARP1 | |
| Fumaric Acid SCHEMBL8092721 | 0.79 | SIGMAR1 (0.83) | SIGMAR1DRD2PPARGPPARAPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355659-B1 | TREATING PSYCHOSIS AND DEMENTIA BY ADMINISTERING | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2002-03-12 | — | — | US | claimed |
| US-6355659-B1 | TREATING PSYCHOSIS AND DEMENTIA BY ADMINISTERING | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2002-03-12 | — | — | US | disclosed |