Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 17/20 | 0.56 |
| ▸ | TMPRSS15 | P98073 | 17/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7895440 | 0.86 | ITGB3 (0.62) | ITGB3ITGA2B | |
| SCHEMBL7673755 | 0.86 | ITGB3 (0.62) | ITGB3ITGA2B | |
| SCHEMBL7665921 | 0.81 | ITGB3 (0.60) | ITGB3ITGA2B | |
| SCHEMBL7670445 | 0.80 | TMPRSS6 (0.51) | PRSS1TMPRSS15ITGB3ITGA2B | |
| SCHEMBL7670690 | 0.80 | TMPRSS6 (0.51) | PRSS1TMPRSS15ITGB3ITGA2B | |
| SCHEMBL7669728 | 0.79 | PLAU (0.45) | PRSS1TMPRSS15ITGB3ITGA2B | |
| SCHEMBL7669205 | 0.78 | TMPRSS15 (0.52) | PRSS1TMPRSS15 | |
| SCHEMBL7670310 | 0.78 | TMPRSS15 (0.52) | PRSS1TMPRSS15 | |
| SCHEMBL7667925 | 0.76 | F2 (0.54) | ITGB3ITGA2B | |
| SCHEMBL7673572 | 0.76 | F2 (0.54) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | claimed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | claimed |
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |