Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS15 | P98073 | 8/20 | 0.52 |
| ▸ | F2 | P00734 | 6/20 | 0.52 |
| ▸ | TMPRSS6 | Q8IU80 | 4/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7670310 | 1.00 | TMPRSS15 (0.52) | TMPRSS15F2TMPRSS6PRSS1ALDH1A1 | |
| SCHEMBL7670445 | 0.88 | TMPRSS6 (0.51) | TMPRSS15F2TMPRSS6PRSS1MMP2 | |
| SCHEMBL7670690 | 0.88 | TMPRSS6 (0.51) | TMPRSS15F2TMPRSS6PRSS1MMP2 | |
| SCHEMBL7669940 | 0.86 | MMP2 (0.55) | ALDH1A1MEP1BADAMTS4MMP2MMP13 | |
| Acetic Acid SCHEMBL7663094 | 0.84 | TMPRSS6 (0.55) | TMPRSS15F2TMPRSS6PRSS1KLK1 | |
| Acetic Acid SCHEMBL7667840 | 0.84 | TMPRSS6 (0.55) | TMPRSS15F2TMPRSS6PRSS1KLK1 | |
| SCHEMBL7665182 | 0.78 | PRSS1 (0.56) | TMPRSS15PRSS1 | |
| SCHEMBL4619647 | 0.78 | MEP1B (0.57) | F2TMPRSS6ALDH1A1MEP1BMMP2 | |
| SCHEMBL8409042 | 0.78 | LMNA (0.60) | F2TMPRSS6ALDH1A1MMP2 | |
| SCHEMBL7665205 | 0.77 | F2 (0.58) | TMPRSS15F2TMPRSS6PRSS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | claimed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | claimed |
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |