Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.54 |
| ▸ | TMPRSS6 | Q8IU80 | 7/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.49 |
| ▸ | HPN | P05981 | 3/20 | 0.48 |
| ▸ | PLAU | P00749 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667925 | 1.00 | F2 (0.54) | F2TMPRSS6ITGB3ITGA2BHPN | |
| SCHEMBL7895440 | 0.88 | ITGB3 (0.62) | F2TMPRSS6ITGB3ITGA2BALDH1A1 | |
| SCHEMBL7673755 | 0.88 | ITGB3 (0.62) | F2TMPRSS6ITGB3ITGA2BALDH1A1 | |
| SCHEMBL7669728 | 0.86 | PLAU (0.45) | F2TMPRSS6ITGB3ITGA2BHPN | |
| SCHEMBL7667927 | 0.84 | ALDH1A1 (0.57) | ALDH1A1MAPTMMP2MMP9CTSL | |
| SCHEMBL7688160 | 0.82 | ALDH1A1 (0.59) | ALDH1A1MAPTMMP2MMP9CTSL | |
| SCHEMBL5090813 | 0.80 | ALDH1A1 (0.59) | ALDH1A1MAPTMMP2MMP9CTSL | |
| SCHEMBL8445738 | 0.78 | CTSL (0.67) | ALDH1A1MAPTMMP2MMP9CTSL | |
| SCHEMBL3441383 | 0.76 | F2 (0.55) | F2ALDH1A1MAPTPLGMMP2 | |
| SCHEMBL7665182 | 0.76 | PRSS1 (0.56) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |