Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.45 |
| ▸ | PDE4A | P27815 | 8/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671642 | 0.84 | ADORA2A (0.42) | ADORA2AADORA2BADORA3 | |
| SCHEMBL7666660 | 0.82 | ADORA2B (0.54) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL7662113 | 0.79 | ADORA1 (0.51) | ADORA2AADORA2BADORA3KMT2A | |
| SCHEMBL7668670 | 0.77 | ADORA2B (0.51) | ADORA2AADORA2BADORA3KMT2A | |
| SCHEMBL7671402 | 0.75 | ADORA1 (0.50) | ADORA2AADORA2BADORA3KMT2A | |
| SCHEMBL8560750 | 0.74 | PDE4A (0.52) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL7669942 | 0.72 | ADORA2A (0.47) | ADORA2AADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL7670431 | 0.71 | ADORA2B (0.54) | ADORA2AADORA2BADORA3KMT2A | |
| SCHEMBL8556980 | 0.71 | ADORA2B (0.51) | ADORA2AADORA2BADORA3KMT2A | |
| SCHEMBL7659412 | 0.71 | ADORA2B (0.45) | ADORA2AADORA2BADORA3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |