Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PARG | Q86W56 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664876 | 0.84 | ADORA1 (0.34) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL193613 | 0.82 | USP2 (0.47) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2USP2 | |
| SCHEMBL7660655 | 0.82 | LMNA (0.41) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL7966994 | 0.81 | USP2 (0.41) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL7978878 | 0.79 | MEN1 (0.38) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL7690322 | 0.78 | NPC1 (0.33) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL7979242 | 0.77 | L3MBTL1 (0.38) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL7979203 | 0.76 | MAPK1 (0.40) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL7685403 | 0.75 | NPC1 (0.36) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL7670733 | 0.72 | ADORA1 (0.34) | ALDH1A1CYP1A2CYP2C9SMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441169-B1 | PHENYL, THIENYL (INCLUDING ALL 3 ISOMERS), THIAZOLYL OR PYRIDYL PYRIMIDINES; PROTECTING PLANTS AGAINST DISEASES CAUSED BY FUNGI, BACTERIA OR VIRUSES | SYNGENTA CROP PROTECTION, INC. | 2002-08-27 | — | — | US | disclosed |
| CN-1269793-A | Pyrimidin-2-oxo-4-one and pyrimidin-2-oxo-4-thione derivatives | NOVARTIS AG (CH) | 2000-10-11 | — | — | CN | disclosed |
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| EP-1015435-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | Novartis AG (CH) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |
| WO-1999011631-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | NOVARTIS AG (CH) | 1999-03-11 | — | — | WO | disclosed |