Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.31 |
| ▸ | PDE4A | P27815 | 2/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664876 | 0.94 | ADORA1 (0.34) | NPC1ALDH1A1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL7685590 | 0.88 | NPC1 (0.32) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL7979242 | 0.85 | L3MBTL1 (0.38) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL7979203 | 0.84 | MAPK1 (0.40) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL7670733 | 0.81 | ADORA1 (0.34) | ALDH1A1SMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL7685403 | 0.80 | NPC1 (0.36) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL7966994 | 0.80 | USP2 (0.41) | NPC1ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL7665387 | 0.78 | ALDH1A1 (0.33) | NPC1ALDH1A1RAB9ASMN1; SMN2NPSR1 | |
| SCHEMBL193613 | 0.77 | USP2 (0.47) | ALDH1A1SMN1; SMN2NPSR1CYP1A2CYP2C9 | |
| SCHEMBL7690572 | 0.76 | CACNA2D1 (0.43) | ALDH1A1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441169-B1 | PHENYL, THIENYL (INCLUDING ALL 3 ISOMERS), THIAZOLYL OR PYRIDYL PYRIMIDINES; PROTECTING PLANTS AGAINST DISEASES CAUSED BY FUNGI, BACTERIA OR VIRUSES | SYNGENTA CROP PROTECTION, INC. | 2002-08-27 | — | — | US | claimed |
| EP-1015435-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | Novartis AG (CH) | 2000-07-05 | — | — | EP | claimed |
| WO-1999011631-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | NOVARTIS AG (CH) | 1999-03-11 | — | — | WO | claimed |
| US-6441169-B1 | PHENYL, THIENYL (INCLUDING ALL 3 ISOMERS), THIAZOLYL OR PYRIDYL PYRIMIDINES; PROTECTING PLANTS AGAINST DISEASES CAUSED BY FUNGI, BACTERIA OR VIRUSES | SYNGENTA CROP PROTECTION, INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1015435-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | Novartis AG (CH) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999011631-A1 | PYRIMIDIN-2-OXY-4-ONE AND PYRIMIDIN-2-OXY-4-THIONE DERIVATIVES | NOVARTIS AG (CH) | 1999-03-11 | — | — | WO | disclosed |