SCHEMBL7665474

SCHEMBL7665474

COc1ccc2c(ccc3cc(OC(F)(F)F)ccc32)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPM1A P35813 1/20 0.54
CYP1A2 P05177 1/20 0.48
CYP2A6 P11509 1/20 0.48
RAD52 P43351 1/20 0.44
KDM4E B2RXH2 2/20 0.44
MEN1 O00255 1/20 0.44
MAPT P10636 1/20 0.44
KMT2A Q03164 1/20 0.44
KIF11 P52732 1/20 0.44
HNF4A P41235 1/20 0.43
MAPK7 Q13164 1/20 0.43
HSD17B1 P14061 1/20 0.43
HSD17B2 P37059 1/20 0.43
GPR3 P46089 1/20 0.42
TRPV1 Q8NER1 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
MTNR1A P48039 1/20 0.41
MTNR1B P49286 1/20 0.41
GSTP1 P09211 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27902298 0.84 CYP2A6 (0.65) CYP1A2CYP2A6RAD52KDM4EMEN1
SCHEMBL7657283 0.84 GPR3 (0.53) PPM1ACYP1A2CYP2A6KDM4EKIF11
SCHEMBL12277498 0.82 CYP2A6 (0.62) CYP1A2CYP2A6RAD52KDM4EMEN1
SCHEMBL3137389 0.82 CYP2A6 (0.62) CYP1A2CYP2A6RAD52KDM4EMEN1
SCHEMBL12259995 0.82 CYP2A6 (0.62) CYP1A2CYP2A6RAD52KDM4EMEN1
SCHEMBL7659214 0.81 CYP1A2 (0.47) PPM1ACYP1A2CYP2A6KDM4EKMT2A
SCHEMBL7658885 0.81 L3MBTL1 (0.47) PPM1ACYP1A2MEN1MAPTKMT2A
SCHEMBL7668224 0.80 L3MBTL1 (0.47) CYP1A2CYP2A6RAD52KDM4EMEN1
SCHEMBL12268988 0.80 CYP2A6 (0.60) CYP1A2CYP2A6RAD52KDM4EMEN1
SCHEMBL7659967 0.78 CA12 (0.43) PPM1AKIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6495220-B2 WITH POSITIVE DIELECTRIC ANISOTROPY AND FAVORABLE VISCOSITY; THERMAL, LIGHT AND ULTRAVIOLET STABILITY; USE IN PORTABLE TELEPHONES AND NOTEBOOK COMPUTERS CLARIANT INTERNATIONAL LTD. (CH) 2002-12-17 US disclosed
US-20010023935-A1 With positive dielectric anisotropy and favorable viscosity; thermal, light and ultraviolet stability; use in portable telephones and notebook computers CLARIANT INTERNATIONAL LTD. (CH) 2001-09-27 US disclosed