SCHEMBL7657283

SCHEMBL7657283

Cc1ccc2c(ccc3cc(OC(F)(F)F)ccc32)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 2/20 0.53
CYP1A2 P05177 4/20 0.46
CYP2A6 P11509 3/20 0.46
KIF11 P52732 1/20 0.42
KDM4E B2RXH2 2/20 0.42
LMNA P02545 2/20 0.42
GAA P10253 2/20 0.42
HSD17B10 Q99714 2/20 0.42
ALDH1A1 P00352 1/20 0.42
HPGD P15428 1/20 0.42
PPM1A P35813 2/20 0.41
TDP1 Q9NUW8 1/20 0.41
PIM1 P11309 1/20 0.39
GRIN2B Q13224 2/20 0.38
CES1 P23141 1/20 0.38
FFAR4 Q5NUL3 1/20 0.38
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
GMNN O75496 1/20 0.37
USP2 O75604 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12369504 0.93 GPR3 (0.59) GPR3CYP1A2CYP2A6KIF11KDM4E
SCHEMBL2662744 0.89 GPR3 (0.56) GPR3CYP1A2CYP2A6KIF11KDM4E
SCHEMBL7665474 0.84 PPM1A (0.54) GPR3CYP1A2CYP2A6KIF11KDM4E
SCHEMBL7658885 0.79 L3MBTL1 (0.47) GPR3CYP1A2KIF11LMNAHSD17B10
SCHEMBL14525519 0.79 GPR3 (0.43) GPR3CYP1A2KIF11KDM4ELMNA
SCHEMBL7659214 0.79 CYP1A2 (0.47) GPR3CYP1A2CYP2A6KIF11KDM4E
SCHEMBL16289920 0.77 CYP1A2 (0.52) GPR3CYP1A2CYP2A6KIF11LMNA
SCHEMBL12433471 0.77 ALDH1A1 (0.49) GPR3CYP1A2CYP2A6KIF11KDM4E
SCHEMBL15869806 0.77 CYP2A6 (0.54) CYP1A2CYP2A6KDM4ELMNAGAA
SCHEMBL7659967 0.77 CA12 (0.43) KIF11PPM1AFFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6495220-B2 WITH POSITIVE DIELECTRIC ANISOTROPY AND FAVORABLE VISCOSITY; THERMAL, LIGHT AND ULTRAVIOLET STABILITY; USE IN PORTABLE TELEPHONES AND NOTEBOOK COMPUTERS CLARIANT INTERNATIONAL LTD. (CH) 2002-12-17 US disclosed
US-20010023935-A1 With positive dielectric anisotropy and favorable viscosity; thermal, light and ultraviolet stability; use in portable telephones and notebook computers CLARIANT INTERNATIONAL LTD. (CH) 2001-09-27 US disclosed