Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.56 |
| ▸ | KIF11 | P52732 | 8/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1686447 | 0.83 | TRPV1 (0.61) | TRPV1KIF11P2RX7CYP11B1CYP11B2 | |
| SCHEMBL766631 | 0.81 | TRPV1 (0.53) | TRPV1 | |
| SCHEMBL766679 | 0.80 | TRPV1 (0.69) | TRPV1KIF11P2RX7 | |
| SCHEMBL766424 | 0.79 | TRPV1 (0.79) | TRPV1 | |
| SCHEMBL766582 | 0.79 | TRPV1 (0.79) | TRPV1 | |
| SCHEMBL1686401 | 0.77 | TRPV1 (0.59) | TRPV1KIF11 | |
| SCHEMBL1686549 | 0.74 | TRPV1 (0.59) | TRPV1KIF11P2RX7CYP11B1CYP11B2 | |
| SCHEMBL766700 | 0.73 | TRPV1 (0.54) | TRPV1KIF11P2RX7CYP11B1CYP11B2 | |
| SCHEMBL13257566 | 0.73 | TRPV1 (0.54) | TRPV1KIF11P2RX7CYP11B1CYP11B2 | |
| SCHEMBL766496 | 0.72 | TRPV1 (0.55) | TRPV1KIF11P2RX7CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-03-22 | — | — | US | disclosed |
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-03-22 | — | — | US | disclosed |
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2012-03-22 | — | — | US | disclosed |
| EP-2393789-A1 | ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES | N.V. Organon (NL) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010091009-A1 | ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | disclosed |
| WO-2010091009-A1 | ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2010-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071481-A1 | ISOXAZOLE-5-CARBOXAMIDE DERIVATIVES | TRPV1, TRPV5, TRPV3 | TRPV1 1/4885KIF11 3415/4885P2RX7 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.