Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | IKBKB | O14920 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28034854 | 0.88 | SCN9A (0.52) | DHODHCTNNB1 | |
| SCHEMBL415485 | 0.85 | KDM4E (0.55) | KDM4ELMNASMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL7729548 | 0.85 | KDM4E (0.50) | KDM4ELMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL28304286 | 0.83 | MAPK1 (0.44) | LMNASMN1; SMN2IKBKBPARP1MEN1 | |
| SCHEMBL28460414 | 0.82 | MKNK1 (0.51) | PARP1DHODHSIRT1 | |
| SCHEMBL11957361 | 0.82 | SMN1; SMN2 (0.49) | KDM4ELMNASMN1; SMN2ALDH1A1GAA | |
| Ethylene SCHEMBL27448159 | 0.82 | KDM4E (0.51) | KDM4ELMNASMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL19663968 | 0.81 | MAPK1 (0.56) | KDM4ELMNAALDH1A1GAAALOX15 | |
| Biphenyl SCHEMBL895843 | 0.81 | BCAT2 (0.46) | KDM4EBCAT2BRD4IKBKBPARP1 | |
| SCHEMBL8913939 | 0.79 | KDM4E (0.45) | KDM4ELMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110023304-A | Calpain regulator and its therapeutical uses | 布莱德治疗公司 | 2019-07-16 | — | — | CN | disclosed |
| CN-109970654-A | A series of substitution 2- phenylpyrazole derivatives and its preparation method and application | 郑州大学 | 2019-07-05 | — | — | CN | disclosed |
| CN-105008344-B | Bruton's tyrosine kinase inhibitor | 辉瑞公司 | 2017-07-25 | — | — | CN | disclosed |
| CN-105008344-A | Bruton's tyrosine kinase inhibitors | PFIZER | 2015-10-28 | — | — | CN | disclosed |
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | disclosed |