Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 6/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 4/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9799881 | 0.87 | ALDH1A1 (0.34) | PARP1KDM4E | |
| SCHEMBL7666259 | 0.81 | KDM4E (0.47) | BCAT2IKBKBPARP1DHODHCHUK | |
| SCHEMBL954343 | 0.81 | BCAT2 (0.47) | BCAT2IKBKBADORA2AMAP2K3PARP1 | |
| Biphenyl SCHEMBL28236210 | 0.76 | BCAT2 (0.40) | BCAT2IKBKBPARP1DHODHCHUK | |
| SCHEMBL23824151 | 0.71 | KDM4E (0.44) | KDM4E | |
| SCHEMBL28760209 | 0.71 | BCAT2 (0.62) | BCAT2IKBKBPARP1DHODHCHUK | |
| Biphenyl SCHEMBL27658278 | 0.70 | PIN1 (0.47) | CASP1KDM4E | |
| SCHEMBL28034854 | 0.70 | SCN9A (0.52) | DHODH | |
| SCHEMBL29936373 | 0.70 | PLA2G10 (0.46) | CDC7 | |
| SCHEMBL4524160 | 0.70 | ALDH1A1 (0.41) | BCAT2IKBKBPARP1CHUKBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2579039-B1 | Neuropeptide release assay for sodium channels | REGENERON PHARMA (US) | 2017-10-25 | — | — | EP | disclosed |
| EP-2631654-B1 | Neuropeptide release assay for sodium channels | REGENERON PHARMA (US) | 2015-04-15 | — | — | EP | disclosed |
| US-8871996-B2 | Mice expressing human voltage-gated sodium channels | REGENERON PHARMACEUTICALS, INC. (US) | 2014-10-28 | — | — | US | disclosed |
| EP-2631654-A1 | Neuropeptide release assay for sodium channels | Regeneron Pharmaceuticals, Inc. (US) | 2013-08-28 | — | — | EP | disclosed |
| US-8486647-B2 | Neuropeptide release assay for sodium channels | REGENERON PHARMACEUTICALS, INC. (US) | 2013-07-16 | — | — | US | disclosed |
| EP-2527842-B1 | Neuropeptide release assay for sodium channels | REGENERON PHARMA (US) | 2013-06-05 | — | — | EP | disclosed |
| EP-2579039-A1 | Neuropeptide release assay for sodium channels | Regeneron Pharmaceuticals, Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| US-20120083000-A1 | Neuropeptide Release Assay For Sodium Channels | REGENERON PHARMACEUTICALS, INC. (US) | 2012-04-05 | — | — | US | disclosed |