Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27886009 | 0.90 | NR4A2 (0.52) | SMN1; SMN2MAPTALDH1A1AXLGAA | |
| SCHEMBL8189911 | 0.90 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTALDH1A1AXLGAA | |
| SCHEMBL28202943 | 0.84 | SLC6A4 (0.53) | SMN1; SMN2MAPTALDH1A1LMNAKMT2A | |
| SCHEMBL11957361 | 0.83 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTALDH1A1GAAPTGS1 | |
| SCHEMBL2921221 | 0.83 | JAK2 (0.57) | SMN1; SMN2MAPTALDH1A1GAALMNA | |
| SCHEMBL7729548 | 0.82 | KDM4E (0.50) | SMN1; SMN2MAPTALDH1A1GAAPTGS1 | |
| SCHEMBL415485 | 0.82 | KDM4E (0.55) | SMN1; SMN2MAPTALDH1A1NR4A2PTGS1 | |
| SCHEMBL8489134 | 0.81 | LMNA (0.46) | SMN1; SMN2MAPTALDH1A1PTGS1LMNA | |
| SCHEMBL7666259 | 0.79 | KDM4E (0.47) | SMN1; SMN2ALDH1A1GAALMNAKDM4E | |
| Ethylene SCHEMBL27448159 | 0.79 | KDM4E (0.51) | SMN1; SMN2MAPTALDH1A1NR4A2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0135838-B1 | 3-PHENYL-4-METHOXYCARBONYL PYRAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR USE AGAINST PLANT GROWTH | BASF Aktiengesellschaft (DE) | 1990-04-18 | — | — | EP | claimed |
| US-4537617-A | HEBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1985-08-27 | — | — | US | claimed |
| CN-110167933-B | As αVAzole amides and amines as integrin inhibitors | 百时美施贵宝公司 | 2022-06-21 | — | — | CN | disclosed |
| EP-3538527-B1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-10-13 | — | — | EP | disclosed |
| US-10851098-B2 | Azole amides and amines as alpha v integrin inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-12-01 | — | — | US | disclosed |
| US-20190256513-A1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2019-08-22 | — | — | US | disclosed |
| EP-2410858-B1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME (US) | 2016-09-07 | — | — | EP | disclosed |
| EP-2410858-B1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME (US) | 2016-09-07 | — | — | EP | disclosed |
| US-8946231-B2 | P2X3, receptor antagonists for treatment of pain | MERCK SHARP & DOHME CORP. (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946231-B2 | P2X3, receptor antagonists for treatment of pain | MERCK SHARP & DOHME CORP. (US) | 2015-02-03 | — | — | US | disclosed |
| EP-2410858-A1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | Merck Sharp & Dohme Corp. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111059-A1 | P2X3 RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME CORP. (US) | 2010-09-30 | — | — | WO | disclosed |
| EP-0135838-B1 | 3-PHENYL-4-METHOXYCARBONYL PYRAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR USE AGAINST PLANT GROWTH | BASF Aktiengesellschaft (DE) | 1990-04-18 | — | — | EP | disclosed |
| EP-0135838-B1 | 3-PHENYL-4-METHOXYCARBONYL PYRAZOLES, PROCESS FOR THEIR PREPARATION AND THEIR USE AGAINST PLANT GROWTH | BASF Aktiengesellschaft (DE) | 1990-04-18 | — | — | EP | disclosed |
| US-4537617-A | HEBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1985-08-27 | — | — | US | disclosed |
| US-4537617-A | HEBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1985-08-27 | — | — | US | disclosed |
| US-4537617-A | HEBICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1985-08-27 | — | — | US | disclosed |
| EP-0135838-A2 | 3-Phenyl-4-methoxycarbonyl pyrazoles, process for their preparation and their use against plant growth | BASF Aktiengesellschaft (DE) | 1985-04-03 | — | — | EP | disclosed |
| EP-0135838-A2 | 3-Phenyl-4-methoxycarbonyl pyrazoles, process for their preparation and their use against plant growth | BASF Aktiengesellschaft (DE) | 1985-04-03 | — | — | EP | disclosed |
| US-4420324-A | HERBICIDES | BASF AKTIENGESELLSCHAFT (US) | 1983-12-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10851098-B2 | Azole amides and amines as alpha v integrin inhibitors | ITGAV, ITGB1, ITGA1 | SMN1; SMN2 3383/4885MAPT 177/4885ALDH1A1 779/4885 |
| US-20190256513-A1 | AZOLE AMIDES AND AMINES AS ALPHA V INTEGRIN INHIBITORS | ITGAV, ITGB1, ITGA1 | SMN1; SMN2 3383/4885MAPT 177/4885ALDH1A1 779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.