Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7666912 | 1.00 | LMNA (0.54) | LMNAALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL9239140 | 0.96 | ALDH1A1 (0.51) | LMNAALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL28512248 | 0.88 | MAPT (0.52) | LMNAALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL9226532 | 0.85 | LMNA (0.51) | LMNAALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL28771675 | 0.83 | ALDH1A1 (0.53) | LMNAALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL8805358 | 0.82 | KMT2A (0.58) | LMNAALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL8805362 | 0.82 | KMT2A (0.58) | LMNAALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL7218667 | 0.82 | AKR1C1 (0.58) | LMNAALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL7666255 | 0.82 | AKR1C1 (0.58) | LMNAALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL4006379 | 0.81 | KMT2A (0.69) | LMNAALDH1A1NPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492531-B1 | THE INVENTION CONCERNS CHOLECYSTOKININ (CCK) ANTAGONISTS USEFUL IN THE TREATMENT OF COGNITIVE DISORDERS. ESPECIALLY USEFUL ARE CCK.SUB.B ANTAGONISTS SUCH AS CI-988. | WARNER-LAMBERT COMPANY | 2002-12-10 | — | — | US | disclosed |
| EP-0729752-A2 | Central cholecystokinin antagonists having pharmaceutical activity | MERCK SHARP & DOHME LTD. (GB) | 1996-09-04 | — | — | EP | disclosed |
| WO-1993012791-A1 | CENTRAL CHOLECYSTOKININ ANTAGONISTS HAVING PHARMACEUTICAL ACTIVITY | MERCK SHARP & DOHME LIMITED (GB) | 1993-07-08 | — | — | WO | disclosed |