Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8805358 | 1.00 | KMT2A (0.58) | KMT2AALDH1A1MEN1HPGDLMNA | |
| SCHEMBL7666255 | 0.86 | AKR1C1 (0.58) | KMT2AALDH1A1MEN1HPGDLMNA | |
| SCHEMBL7218667 | 0.86 | AKR1C1 (0.58) | KMT2AALDH1A1MEN1HPGDLMNA | |
| SCHEMBL7666912 | 0.82 | LMNA (0.54) | KMT2AALDH1A1MEN1HPGDLMNA | |
| SCHEMBL7666908 | 0.82 | LMNA (0.54) | KMT2AALDH1A1MEN1HPGDLMNA | |
| SCHEMBL11505978 | 0.81 | MAPT (0.49) | KMT2AALDH1A1MEN1HPGDLMNA | |
| SCHEMBL9239140 | 0.79 | ALDH1A1 (0.51) | KMT2AALDH1A1MEN1HPGDLMNA | |
| SCHEMBL27638437 | 0.78 | TRPA1 (0.48) | KMT2AALDH1A1MEN1HPGDLMNA | |
| SCHEMBL9477461 | 0.77 | CA1 (0.52) | KMT2AALDH1A1MEN1HPGDLMNA | |
| SCHEMBL9477455 | 0.77 | CA1 (0.52) | KMT2AALDH1A1MEN1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0809636-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-12-03 | — | — | EP | disclosed |
| WO-1996025405-A1 | SUBSTITUTED ISOXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-22 | — | — | WO | disclosed |