Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.33 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667545 | 1.00 | SMN1; SMN2 (0.37) | SMN1; SMN2SLC22A6CACNA2D1CACNB3CACNA1C | |
| SCHEMBL9651906 | 1.00 | SMN1; SMN2 (0.37) | SMN1; SMN2SLC22A6CACNA2D1CACNB3CACNA1C | |
| SCHEMBL9651309 | 0.80 | CA2 (0.30) | — | |
| SCHEMBL7668711 | 0.80 | CA2 (0.30) | — | |
| SCHEMBL7668714 | 0.80 | CA2 (0.30) | — | |
| SCHEMBL9652086 | 0.78 | TSHR (0.37) | MAPT | |
| SCHEMBL9652087 | 0.77 | LMNA (0.34) | SMN1; SMN2SLC22A6TDP1MAPTALDH1A1 | |
| SCHEMBL7254593 | 0.76 | SLC22A6 (0.33) | SMN1; SMN2SLC22A6CACNA2D1CACNB3CACNA1C | |
| SCHEMBL13297198 | 0.75 | FNTA (0.36) | MAPT | |
| SCHEMBL31341290 | 0.75 | GABRP (0.38) | SLC22A6ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387934-B1 | RHEUMATIC DISEASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-05-14 | — | — | US | disclosed |
| US-6172103-B1 | TREATING BONE DISORDERS, OSTEOPOROSIS, AND ARTHRITIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-01-09 | — | — | US | disclosed |
| US-6121316-A | BONE DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-09-19 | — | — | US | disclosed |
| US-5145957-A | Carbapenicillin intermediates | MERCK & CO., INC. (US) | 1992-09-08 | — | — | US | disclosed |
| EP-0333268-A1 | Process for synthesis of a chiral 3-beta hydrogen (3R) 4-aroyloxy azetidinone | MERCK & CO. INC. (US) | 1989-09-20 | — | — | EP | disclosed |