Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 4/20 | 0.66 |
| ▸ | MMP2 | P08253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPN | P05981 | 4/20 | 0.51 |
| ▸ | PLAU | P00749 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30689105 | 0.89 | ALDH1A1 (0.56) | MMP9MMP2MAPTLMNACTSL | |
| SCHEMBL7667779 | 0.88 | MMP9 (0.52) | MMP9MMP2MAPTLMNAMEN1 | |
| SCHEMBL7674729 | 0.82 | MMP9 (0.66) | MMP9MMP2MAPTLMNAHPN | |
| SCHEMBL7670593 | 0.81 | LMNA (0.55) | MMP9MMP2MAPTLMNAHPN | |
| SCHEMBL7675164 | 0.80 | MMP9 (0.52) | MMP9MMP2MAPTLMNAHPN | |
| SCHEMBL5093780 | 0.80 | MMP9 (1.00) | MMP9MMP2MAPTHPNPLAU | |
| SCHEMBL7669356 | 0.80 | MMP9 (1.00) | MMP9MMP2MAPTHPNPLAU | |
| SCHEMBL7583642 | 0.79 | MMP9 (0.70) | MMP9MMP2 | |
| SCHEMBL5221010 | 0.78 | LMNA (0.55) | MMP9MMP2MAPTLMNAHPN | |
| SCHEMBL7673629 | 0.78 | MMP9 (0.76) | MMP9MMP2MAPTHPNPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |