Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | VKORC1 | Q9BQB6 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7672504 | 0.87 | NR1H2 (0.40) | ALDH1A1 | |
| SCHEMBL7671417 | 0.82 | GAA (0.39) | ALOX5PLA2G7ALDH1A1VKORC1TP53 | |
| SCHEMBL7669227 | 0.80 | VKORC1 (0.38) | ALOX5PLA2G7ALDH1A1VKORC1TP53 | |
| SCHEMBL7666716 | 0.80 | SMN1; SMN2 (0.39) | ALOX5PLA2G7ALDH1A1VKORC1TP53 | |
| SCHEMBL7663982 | 0.78 | TP53 (0.39) | VKORC1TP53PDE7A | |
| SCHEMBL7666493 | 0.74 | GABRA1 (0.40) | ALOX5PLA2G7VKORC1CYP1B1 | |
| SCHEMBL7668181 | 0.73 | PKM (0.36) | ALDH1A1PKM | |
| SCHEMBL7672566 | 0.73 | BRD4 (0.37) | ALDH1A1PKM | |
| SCHEMBL7665153 | 0.71 | KCNA5 (0.35) | PLA2G7PKM | |
| SCHEMBL7669021 | 0.71 | KCNA5 (0.33) | PLA2G7PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476021-B1 | Compounds having cGMP-PDE inhibitory effect | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-11-05 | — | — | US | disclosed |
| EP-1048666-A1 | NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2000-11-02 | — | — | EP | disclosed |