Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.31 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664380 | 0.85 | TAAR1 (0.38) | TAAR1KCNH2IGF1RALOX15DAO | |
| SCHEMBL1776797 | 0.83 | TRPA1 (0.34) | TAAR1CYP1A2CYP2A6TRPA1 | |
| SCHEMBL7671780 | 0.82 | TUBB4A (0.45) | TAAR1HRH3IGF1RALOX15DAO | |
| SCHEMBL311359 | 0.77 | TRPA1 (0.38) | TAAR1CYP1A2CYP2A6TRPA1RAPGEF4 | |
| SCHEMBL7669645 | 0.77 | MAOB (0.44) | TAAR1CYP1A2CYP2A6 | |
| SCHEMBL1779587 | 0.77 | SKP2 (0.34) | CYP1A2CYP2A6TRPA1HSD17B10 | |
| SCHEMBL7674074 | 0.76 | CYP19A1 (0.50) | CYP1A2DAO | |
| SCHEMBL6546215 | 0.74 | TAAR1 (0.56) | TAAR1CYP1A2CYP2A6CHKAHRH3 | |
| SCHEMBL1777563 | 0.74 | PTGS2 (0.39) | KCNH2ALOX15HSD17B10 | |
| SCHEMBL1369825 | 0.74 | CNR1 (0.41) | GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6395730-B1 | CARDIOVASCULAR DISORDERS | ICAGEN, INC. | 2002-05-28 | — | — | US | disclosed |
| US-6174908-B1 | TREATING DISEASE, CONDITION, OR DISORDER WHICH RESPONDS TO INHIBITION OF POTASSIUM CHANNEL FUNCTION BY ADMINISTERING THIAZOLIDONE OR METATHIAZONONE COMPOUND, ITS SALT, AMIDE, ESTER, COMPLEX, CHELATE, HYDRATE, STEREOISOMER, METABOLITE | ICAGEN, INC. | 2001-01-16 | — | — | US | disclosed |