Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.63 |
| ▸ | MAPT | P10636 | 9/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.58 |
| ▸ | MEN1 | O00255 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673541 | 0.83 | LMNA (0.69) | LMNAMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7582747 | 0.82 | LMNA (0.65) | LMNAKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7667947 | 0.80 | NPC1 (0.53) | LMNAKMT2ASMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL7674757 | 0.80 | SMN1; SMN2 (0.54) | LMNAKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7663139 | 0.80 | POLB (0.62) | LMNAKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7663740 | 0.80 | ALDH1A1 (0.65) | LMNAKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7584228 | 0.80 | MAPT (0.57) | LMNAMAPTKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL7669640 | 0.79 | GHSR (0.53) | LMNAMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL7671600 | 0.79 | ALDH1A1 (0.51) | LMNAKMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7670521 | 0.79 | MEN1 (0.57) | LMNAKMT2ASMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403644-B1 | FOR PREVENTION AND/OR TREATMENT OF DISEASES INDUCED BY OVEREXPRESSION AND EXCESS ACTIVITY OF MATRIX METALLOPROTEINASE; FOR EXAMPLE, RHEUMATOID, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| US-6177466-B1 | Sulfonylamino acid derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0757037-A2 | Sulfonylamino acid derivatives as metalloproteinase inhibitors | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-05 | — | — | EP | disclosed |