Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 8/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15201912 | 0.85 | GABRA1 (0.45) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL5228078 | 0.79 | GABRG2 (0.44) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7669649 | 0.78 | RAB9A (0.35) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL19575097 | 0.77 | GABRG2 (0.67) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7672131 | 0.74 | GABRG2 (0.68) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7665902 | 0.74 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7483435 | 0.74 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7667586 | 0.73 | GABRA1 (0.66) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL19575090 | 0.73 | GABRA1 (0.63) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL2461269 | 0.71 | GABRG2 (1.00) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355638-B1 | COGNITION ACTIVATORS | MERCK SHARP & DOHME LTD. (GB) | 2002-03-12 | — | — | US | disclosed |