Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669971 | 0.78 | GABRA1 (0.55) | RAB9AKDM4ENPC1GABRA1GABRG2 | |
| SCHEMBL7483435 | 0.72 | GABRA1 (0.57) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL7690061 | 0.71 | GABRA1 (0.40) | RAB9AKDM4ENPC1GABRA1GABRG2 | |
| SCHEMBL1715299 | 0.63 | TSHR (0.44) | RAB9ANPC1LMNACYP2C19ALDH1A1 | |
| SCHEMBL26970922 | 0.61 | LMNA (0.44) | RAB9ANPC1LMNAALDH1A1MAPT | |
| SCHEMBL28398773 | 0.60 | CYP2C19 (0.43) | LMNACYP2C19P2RY12ALDH1A1HPGD | |
| SCHEMBL3057367 | 0.60 | PKM (0.46) | RAB9ANPC1LMNACYP2C19PTGS2 | |
| SCHEMBL7673883 | 0.59 | GABRA1 (0.44) | RAB9AKDM4ENPC1GABRA1GABRG2 | |
| SCHEMBL30877380 | 0.59 | RAPGEF4 (0.48) | RAB9AKDM4ENPC1LMNAPTGS2 | |
| SCHEMBL9296010 | 0.59 | KEAP1 (0.44) | LMNACYP2C19P2RY12ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355638-B1 | COGNITION ACTIVATORS | MERCK SHARP & DOHME LTD. (GB) | 2002-03-12 | — | — | US | disclosed |