Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | HTR6 | P50406 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 2/20 | 0.60 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.59 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7669650 | 0.90 | POLB (0.81) | POLBLMNAALDH1A1MAPTHPGD | |
| SCHEMBL7675868 | 0.89 | POLB (0.80) | POLBLMNAALDH1A1MAPTKMT2A | |
| SCHEMBL7669051 | 0.81 | HTR6 (0.78) | POLBLMNAALDH1A1MAPTHPGD | |
| SCHEMBL3756898 | 0.78 | POLB (0.84) | POLBLMNAALDH1A1MAPTHPGD | |
| SCHEMBL7665354 | 0.77 | ALDH1A1 (0.78) | POLBLMNAALDH1A1MAPTHPGD | |
| SCHEMBL3766151 | 0.76 | TP53 (0.91) | POLBALDH1A1MAPTHPGDNPSR1 | |
| SCHEMBL3760191 | 0.76 | MAPT (1.00) | ALDH1A1MAPTHPGDNPSR1KMT2A | |
| SCHEMBL7665352 | 0.74 | ALDH1A1 (0.84) | POLBLMNAALDH1A1MAPTHPGD | |
| SCHEMBL7674814 | 0.74 | MAPT (0.70) | POLBLMNAALDH1A1MAPTHPGD | |
| SCHEMBL3755285 | 0.73 | L3MBTL1 (0.81) | POLBALDH1A1MAPTHTR6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441013-B1 | 5-HT6 RECEPTOR ANTAGONISTS FOR TREATING CENTRAL NERVOUS SYSTEM DISORDERS | MERCK PATENT GMBH (DE) | 2002-08-27 | — | — | US | disclosed |
| EP-1140875-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GmbH (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037452-A1 | SULPHONYLOXAZOLAMINES AS THERAPEUTIC ACTIVE INGREDIENTS | MERCK PATENT GMBH (DE) | 2000-06-29 | — | — | WO | disclosed |