Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 2/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | AGXT | P21549 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7003301 | 0.88 | ADORA2A (0.35) | PDE1BPDE1APDE1CADORA2ANPBWR1 | |
| SCHEMBL7822690 | 0.80 | P2RX7 (0.38) | POLBMAPTTP53MEN1KMT2A | |
| SCHEMBL7662109 | 0.74 | ADORA1 (0.48) | ADORA2AMEN1KMT2ALMNA | |
| SCHEMBL8567698 | 0.72 | ADORA1 (0.48) | ADORA2AMEN1KMT2ALMNA | |
| SCHEMBL7671571 | 0.71 | TLR7 (0.45) | PDE1BPDE1APDE1CNPBWR1POLB | |
| SCHEMBL6996678 | 0.70 | ABL1 (0.42) | TYMSSIRT5MAPTPNPMEN1 | |
| SCHEMBL7665749 | 0.66 | ADORA2B (0.43) | ADORA2APOLBSIRT1SIRT3SIRT5 | |
| SCHEMBL6996703 | 0.65 | SIRT1 (0.46) | PDE1BPDE1APDE1CADORA2ASIRT1 | |
| SCHEMBL34413 | 0.64 | IDO1 (0.67) | IDO1AGXTTP53 | |
| Potassium SCHEMBL1477050 | 0.62 | IDO1 (0.64) | IDO1AGXTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087973-B1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-08 | — | — | EP | disclosed |
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |
| EP-1087973-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | Boehringer Ingelheim Pharma KG (DE) | 2001-04-04 | — | — | EP | disclosed |
| WO-2000012511-A1 | IMIDAZOTRIAZOLOPYRIMIDINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-03-09 | — | — | WO | disclosed |
| WO-1999065912-A1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1999-12-23 | — | — | WO | disclosed |