Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 12/20 | 0.59 |
| ▸ | HTR2C known ✓ | P28335 | 12/20 | 0.59 |
| ▸ | HTR2B known ✓ | P41595 | 11/20 | 0.59 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.76 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.76 |
| ▸ | GFER | P55789 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7844149 | 1.00 | LMNA (0.76) | LMNAPMP22NPSR1GFERHTR2A | |
| Fumaric Acid SCHEMBL7844154 | 1.00 | LMNA (0.76) | LMNAPMP22NPSR1GFERHTR2A | |
| Fumaric Acid SCHEMBL7671699 | 1.00 | LMNA (0.76) | LMNAPMP22NPSR1GFERHTR2A | |
| SCHEMBL905861 | 0.89 | HTR2A (0.71) | LMNAPMP22NPSR1GFERHTR2A | |
| Fumaric Acid SCHEMBL7676268 | 0.86 | HTR2A (0.81) | LMNAPMP22NPSR1GFERHTR2A | |
| Fumaric Acid SCHEMBL7676257 | 0.86 | HTR2A (0.81) | LMNAPMP22NPSR1GFERHTR2A | |
| Fumaric Acid SCHEMBL7673882 | 0.84 | LMNA (0.71) | LMNAPMP22NPSR1GFERHTR2A | |
| Fumaric Acid SCHEMBL7673894 | 0.84 | LMNA (0.71) | LMNAPMP22NPSR1GFERHTR2A | |
| Fumaric Acid SCHEMBL7671704 | 0.81 | LMNA (0.51) | LMNAPMP22NPSR1GFERHDAC1 | |
| Fumaric Acid SCHEMBL7673810 | 0.81 | LMNA (0.66) | LMNAPMP22NPSR1GFERHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380238-B1 | FOR THERAPY OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS, AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-30 | — | — | US | disclosed |