Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 1/20 | 0.42 |
| ▸ | KMO | O15229 | 4/20 | 0.68 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 5/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8959483 | 0.89 | KMO (0.53) | KMOACLYMCL1OXER1LMNA | |
| Fumaric Acid SCHEMBL8959489 | 0.89 | KMO (0.53) | KMOACLYMCL1OXER1LMNA | |
| Fumaric Acid SCHEMBL7677266 | 0.84 | KMO (0.47) | KMOHTR7LMNAHTR6 | |
| Fumaric Acid SCHEMBL7678483 | 0.83 | KMO (0.60) | KMOACLYMCL1HTR7HTR6 | |
| Fumaric Acid SCHEMBL8959632 | 0.83 | HDAC6 (0.54) | KMOLMNAHDAC1HDAC6 | |
| Fumaric Acid SCHEMBL8959620 | 0.83 | HDAC6 (0.54) | KMOLMNAHDAC1HDAC6 | |
| Fumaric Acid SCHEMBL7673295 | 0.82 | KMO (0.58) | KMOACLYMCL1HTR7OXER1 | |
| Fumaric Acid SCHEMBL7997834 | 0.81 | HTR2C (0.61) | KMO | |
| Fumaric Acid SCHEMBL7997829 | 0.81 | HTR2C (0.61) | KMO | |
| Fumaric Acid SCHEMBL7678479 | 0.80 | KMO (0.56) | KMOACLYMCL1HTR7OXER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380238-B1 | FOR THERAPY OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS, AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-30 | — | — | US | disclosed |
| EP-1109784-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012475-A1 | INDOLINE DERIVATIVES AS 5-HT2B AND/OR 5-HT2C RECEPTOR LIGANDS | VERNALIS RESEARCH LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |