Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.62 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | BID | P55957 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CTSG | P08311 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7516484 | 0.86 | MAPT (0.50) | CCR2TSHRMAPT | |
| SCHEMBL6959828 | 0.77 | CCR2 (1.00) | CCR2NOD1TSHRACLYKMT2A | |
| SCHEMBL6953098 | 0.76 | CCR2 (0.75) | CCR2ABCB11ACLYBCL2BID | |
| SCHEMBL6596517 | 0.75 | CCR2 (0.73) | CCR2NOD1ABCB11ACLYBCL2 | |
| SCHEMBL7050238 | 0.70 | CCR2 (0.56) | CCR2NOD1TSHRPTGDR2KMT2A | |
| SCHEMBL7829429 | 0.67 | CCR2 (0.66) | CCR2ABCB11ACLYKMT2ABCL2 | |
| SCHEMBL1340122 | 0.66 | KDM1A (0.64) | TSHRMCL1KDM1ARCOR1L3MBTL1 | |
| SCHEMBL6963990 | 0.63 | CCR2 (0.74) | CCR2NOD1KMT2ABCL2BID | |
| SCHEMBL13802522 | 0.63 | CCR2 (0.76) | CCR2NOD1TSHRACLYBCL2 | |
| SCHEMBL6964954 | 0.63 | CCR2 (0.56) | CCR2NOD1ACLYFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479527-B1 | Bicyclic pyrrole derivatives as MCP-1 inhibitors | ASTRAZENECA UK LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |
| EP-1056451-A1 | BICYCLIC PYRROLE DERIVATIVES AS MCP-1 INHIBITORS | AstraZeneca UK Limited (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999040914-A1 | BICYCLIC PYRROLE DERIVATIVES AS MCP-1 INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |