Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674077 | 0.86 | CCR2 (0.62) | MAPTTSHRCCR2 | |
| SCHEMBL6963990 | 0.79 | CCR2 (0.74) | MAPTALDH1A1CCR2 | |
| SCHEMBL6964954 | 0.78 | CCR2 (0.56) | CCR2 | |
| SCHEMBL6595442 | 0.77 | CCR2 (0.55) | ALDH1A1TSHRCCR2 | |
| SCHEMBL6960221 | 0.76 | CCR2 (0.51) | MAPTALDH1A1TSHRCCR2 | |
| SCHEMBL6953247 | 0.74 | CCR2 (0.48) | ALDH1A1TSHRCCR2 | |
| SCHEMBL7517302 | 0.74 | MAPT (0.80) | MAPTALDH1A1TSHRTP53THRB | |
| SCHEMBL7049774 | 0.73 | SLC6A2 (0.42) | MAPTALDH1A1TSHRCCR2SMN1; SMN2 | |
| SCHEMBL6598140 | 0.70 | CCR2 (0.54) | CCR2 | |
| SCHEMBL12499937 | 0.70 | KDM1A (0.59) | MAPTALDH1A1TSHRTP53THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056451-B1 | BICYCLIC PYRROLE DERIVATIVES AS MCP-1 INHIBITORS | ASTRAZENECA UK LTD (GB) | 2002-11-13 | — | — | EP | disclosed |
| US-6479527-B1 | Bicyclic pyrrole derivatives as MCP-1 inhibitors | ASTRAZENECA UK LIMITED (GB) | 2002-11-12 | — | — | US | disclosed |
| EP-1056451-A1 | BICYCLIC PYRROLE DERIVATIVES AS MCP-1 INHIBITORS | AstraZeneca UK Limited (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999040914-A1 | BICYCLIC PYRROLE DERIVATIVES AS MCP-1 INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |