Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.74 |
| ▸ | NOD1 | Q9Y239 | 5/20 | 0.60 |
| ▸ | NOD2 | Q9HC29 | 4/20 | 0.60 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | BID | P55957 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964954 | 0.87 | CCR2 (0.56) | CCR2NOD1NOD2PTGS2 | |
| SCHEMBL6595442 | 0.86 | CCR2 (0.55) | CCR2NOD1NOD2ALDH1A1HDAC3 | |
| SCHEMBL6965196 | 0.86 | NOD2 (0.60) | CCR2NOD1NOD2BCL2BID | |
| SCHEMBL6959828 | 0.85 | CCR2 (1.00) | CCR2NOD1NOD2BCL2BID | |
| SCHEMBL9617940 | 0.85 | NOD2 (0.64) | CCR2NOD1NOD2BCL2BID | |
| SCHEMBL14627380 | 0.84 | NOD1 (0.78) | CCR2NOD1NOD2BCL2BID | |
| SCHEMBL10767782 | 0.83 | NOD1 (0.62) | CCR2NOD1NOD2BCL2BID | |
| SCHEMBL6960221 | 0.83 | CCR2 (0.51) | CCR2NOD1NOD2ALDH3A1ALDH1A1 | |
| SCHEMBL6598140 | 0.83 | CCR2 (0.54) | CCR2NOD1NOD2BCL2BID | |
| SCHEMBL6953247 | 0.80 | CCR2 (0.48) | CCR2NOD1NOD2ALDH3A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001935-B1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2003-10-08 | — | — | EP | disclosed |
| US-6288103-B1 | MONOCYTE CHEMOATTRACTANT PROTEINS ANTAGONIST SUCH AS N-(3-CHLOROPHENYLSULPHONYL)INDOLE-2-CARBOXYLIC ACID; ANTIINFLAMMATORY AGENTS | ZENECA LIMITED (GB) | 2001-09-11 | — | — | US | disclosed |
| EP-1001935-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999007678-A1 | INDOLE DERIVATIVES AS MCP-1 RECEPTOR ANTAGONISTS | ZENECA LIMITED (GB) | 1999-02-18 | — | — | WO | disclosed |