Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 4/20 | 0.50 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.37 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 3/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681774 | 0.84 | CRHR1 (0.48) | CRHR1OPRK1HRH4 | |
| SCHEMBL7679988 | 0.84 | CRHR1 (0.43) | CRHR1SSTR2KHKOPRM1OPRD1 | |
| SCHEMBL1637888 | 0.83 | CRHR1 (0.49) | CRHR1PDE10A | |
| SCHEMBL7682689 | 0.81 | CRHR1 (0.51) | CRHR1PDE10A | |
| SCHEMBL7682520 | 0.79 | CRHR1 (0.56) | CRHR1HRH4 | |
| SCHEMBL7684967 | 0.78 | CRHR1 (0.52) | CRHR1 | |
| SCHEMBL7560969 | 0.74 | CRHR1 (0.59) | CRHR1 | |
| SCHEMBL7681407 | 0.74 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL7674966 | 0.73 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL7555469 | 0.73 | CRHR1 (0.58) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362186-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-03-26 | — | — | US | claimed |
| US-6362186-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-03-26 | — | — | US | disclosed |
| US-6147085-A | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives | NEUROGEN CORPORATION (US) | 2000-11-14 | — | — | US | disclosed |