Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.52 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.35 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7674376 | 0.78 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL7682520 | 0.77 | CRHR1 (0.56) | CRHR1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL1637888 | 0.77 | CRHR1 (0.49) | CRHR1MAP2K7 | |
| SCHEMBL7681774 | 0.76 | CRHR1 (0.48) | CRHR1PDK2PDK4MAP2K7MEN1 | |
| SCHEMBL7682689 | 0.75 | CRHR1 (0.51) | CRHR1NPY5RCYP3A4 | |
| SCHEMBL7678166 | 0.74 | CRHR1 (0.41) | CRHR1KDM4EHPGDMEN1LMNA | |
| SCHEMBL7681407 | 0.74 | CRHR1 (0.54) | CRHR1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL7674966 | 0.73 | CRHR1 (0.54) | CRHR1 | |
| SCHEMBL7783143 | 0.72 | CRHR1 (0.51) | CRHR1 | |
| SCHEMBL7783145 | 0.72 | CRHR1 (0.51) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6362186-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-03-26 | — | — | US | claimed |
| US-6362186-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-03-26 | — | — | US | disclosed |
| US-6147085-A | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives | NEUROGEN CORPORATION (US) | 2000-11-14 | — | — | US | disclosed |