Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.37 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.36 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.35 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679938 | 0.83 | CRHR1 (0.47) | NCF1CRHR1 | |
| SCHEMBL7677559 | 0.83 | CRHR1 (0.45) | NCF1CRHR1HSD17B10MAPK1HTR1A | |
| SCHEMBL7679988 | 0.82 | CRHR1 (0.43) | NCF1CRHR1ACVR1 | |
| SCHEMBL7681552 | 0.82 | NCF1 (0.52) | NCF1CRHR1HSD17B10HPGDHTR1A | |
| SCHEMBL7677542 | 0.81 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL7684787 | 0.80 | NCF1 (0.55) | NCF1CRHR1HTR1A | |
| SCHEMBL7677573 | 0.80 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL7678166 | 0.77 | CRHR1 (0.41) | NCF1CRHR1HRH3HPGDL3MBTL1 | |
| SCHEMBL7684798 | 0.73 | CRHR1 (0.51) | CRHR1HSD17B10HPGDL3MBTL1KDM4E | |
| SCHEMBL7674360 | 0.73 | CRHR1 (0.39) | CRHR1HPGDL3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147085-A | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives | NEUROGEN CORPORATION (US) | 2000-11-14 | — | — | US | claimed |
| US-6362186-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-03-26 | — | — | US | disclosed |
| US-6147085-A | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives | NEUROGEN CORPORATION (US) | 2000-11-14 | — | — | US | disclosed |