Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7675191 | 0.85 | CRHR1 (0.39) | CRHR1KDM4EMEN1LMNAHPGD | |
| SCHEMBL7674360 | 0.85 | CRHR1 (0.39) | CRHR1KDM4EMEN1LMNAHPGD | |
| SCHEMBL7674433 | 0.77 | NCF1 (0.41) | CRHR1KDM4EHPGDKMT2AL3MBTL1 | |
| SCHEMBL7681552 | 0.76 | NCF1 (0.52) | CRHR1KDM4ELMNAHPGDNCF1 | |
| SCHEMBL7679938 | 0.76 | CRHR1 (0.47) | CRHR1NCF1 | |
| SCHEMBL7677559 | 0.74 | CRHR1 (0.45) | CRHR1KDM4ELMNAKMT2ANCF1 | |
| SCHEMBL7684787 | 0.74 | NCF1 (0.55) | CRHR1NCF1HTR6 | |
| SCHEMBL7679988 | 0.74 | CRHR1 (0.43) | CRHR1NCF1HTR6 | |
| SCHEMBL7684967 | 0.74 | CRHR1 (0.52) | CRHR1KDM4EMEN1LMNAHPGD | |
| SCHEMBL7677573 | 0.73 | CRHR1 (0.39) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147085-A | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives | NEUROGEN CORPORATION (US) | 2000-11-14 | — | — | US | claimed |
| US-6362186-B1 | PSYCHOLOGICAL DISORDERS | NEUROGEN CORPORATION | 2002-03-26 | — | — | US | disclosed |
| US-6147085-A | Aminoalkyl substituted 9H-pyridino[2,3-b] indole and 9H-pyrimidino[4,5-b] indole derivatives | NEUROGEN CORPORATION (US) | 2000-11-14 | — | — | US | disclosed |