Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7677849 | 0.83 | BCHE (0.51) | BCHEMEN1KMT2AATMOPRD1 | |
| SCHEMBL7679291 | 0.81 | APP (0.52) | APPKMT2AL3MBTL1MAPTOPRD1 | |
| SCHEMBL7678227 | 0.79 | APP (0.50) | APPMEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL21581202 | 0.79 | OPRD1 (0.63) | APPMAPTOPRD1OPRK1OPRM1 | |
| SCHEMBL8915496 | 0.75 | OPRL1 (0.53) | APPMEN1KMT2AL3MBTL1MAPT | |
| SCHEMBL6247508 | 0.75 | APP (0.60) | APPL3MBTL1MAPTGAATSHR | |
| SCHEMBL6153677 | 0.74 | APP (0.50) | APPL3MBTL1MAPTGAATSHR | |
| SCHEMBL22874143 | 0.73 | APP (0.56) | APPL3MBTL1MAPTOPRD1OPRK1 | |
| SCHEMBL13228095 | 0.73 | HDAC1 (0.54) | APPL3MBTL1MAPTGAASMN1; SMN2 | |
| SCHEMBL7680939 | 0.73 | OPRM1 (0.46) | BCHEKMT2AOPRM1GAACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387893-B1 | ADRENERGIC BLOCKING AGENT; BENIGN PROSATATIC HYPERPLASIA | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |