Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.45 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7679291 | 0.79 | APP (0.52) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7674584 | 0.79 | APP (0.52) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL21581202 | 0.76 | OPRD1 (0.63) | APPOPRD1OPRK1OPRM1TSHR | |
| SCHEMBL8915496 | 0.73 | OPRL1 (0.53) | APPL3MBTL1OPRD1OPRK1OPRM1 | |
| SCHEMBL6247508 | 0.73 | APP (0.60) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL22874143 | 0.71 | APP (0.56) | APPL3MBTL1OPRD1OPRK1OPRM1 | |
| SCHEMBL4977356 | 0.70 | HRH3 (0.55) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL4977361 | 0.70 | HRH3 (0.55) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6816262 | 0.70 | L3MBTL1 (0.60) | APPPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9528495 | 0.70 | APP (0.66) | APPPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387893-B1 | ADRENERGIC BLOCKING AGENT; BENIGN PROSATATIC HYPERPLASIA | MERCK & CO., INC. | 2002-05-14 | — | — | US | disclosed |