Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 6/20 | 0.42 |
| ▸ | BCHE | P06276 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7671504 | 0.93 | MAPT (0.42) | MAPTALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7672920 | 0.87 | ACHE (0.55) | MAPTALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7670851 | 0.86 | ALDH1A1 (0.46) | MAPTALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7676828 | 0.85 | PTGS1 (0.47) | MAPTALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7676256 | 0.84 | PTGS1 (0.45) | MAPTALDH1A1LMNAGAAMEN1 | |
| SCHEMBL6735126 | 0.81 | MAPT (0.40) | MAPTALDH1A1LMNAGAAMEN1 | |
| SCHEMBL6705187 | 0.81 | MAPT (0.50) | MAPTALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7668333 | 0.79 | MAPT (0.48) | MAPTALDH1A1LMNAGAAMEN1 | |
| SCHEMBL7669639 | 0.78 | ACHE (0.42) | MAPTALDH1A1ACHEBCHEHPGD | |
| SCHEMBL7670157 | 0.76 | ALDH1A1 (0.47) | MAPTALDH1A1LMNAGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444670-B2 | ENZYME INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES; ANTI-DIABETIC AGENTS; TREATMENT OF INSULIN RESISTANCE ASSOCIATED WITH OBESITY, GLUCOSE INTOLERANCE, DIABETES MELLITUS, HYPERTENSION AND ISCHEMIC DISEASES OF VESSELS | WYETH | 2002-09-03 | — | — | US | disclosed |
| US-20020002187-A1 | Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin-resistance and hyperglycemia | WYETH | 2002-01-03 | — | — | US | disclosed |
| US-6251936-B1 | ADMINISTERING TO THE PATIENT SUFFERING FROM METABOLIC DISORDERS MEDIATED BY INSULIN RESISTANCE OR HYPERGLYCEMIA A BENZENE OR PYRIDINE SUBSTITUTED INDOLE OR BENZOTHIOPHENE DERIVATIVES OR SALTS | AMERICAN HOME PRODUCTS CORPORATION | 2001-06-26 | — | — | US | disclosed |
| EP-1077969-A1 | BENZOTHIOPHENES, BENZOFURANS, AND INDOLES USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999061435-A1 | BENZOTHIOPHENES, BENZOFURANS, AND INDOLES USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020002187-A1 | Benzothiophenes, benzofurans, and indoles useful in the treatment of insulin-resistance and hyperglycemia | IRS1, INSR, GPR119 | MAPT 4113/4885ALDH1A1 1497/4885LMNA 3357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.