Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 18/20 | 0.67 |
| ▸ | AR | P10275 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9370506 | 0.80 | PGR (1.00) | PGRKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL30950987 | 0.72 | PNMT (0.52) | — | |
| SCHEMBL6014131 | 0.72 | PNMT (0.52) | — | |
| SCHEMBL11678763 | 0.71 | PNMT (0.47) | KDM4EALDH1A1MAPTHPGDLMNA | |
| SCHEMBL30973139 | 0.71 | KDM4E (0.83) | PGRARKDM4EALDH1A1MAPT | |
| SCHEMBL12727213 | 0.70 | ALDH1A1 (0.45) | ARALDH1A1MAPT | |
| SCHEMBL4189738 | 0.69 | PGR (1.00) | PGRARKDM4EALDH1A1MAPT | |
| SCHEMBL4179126 | 0.69 | PGR (0.71) | PGRARKDM4EALDH1A1MAPT | |
| SCHEMBL11676256 | 0.66 | PNMT (0.47) | ALDH1A1 | |
| SCHEMBL2355804 | 0.65 | SMN1; SMN2 (0.53) | KDM4EALDH1A1MAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448405-B1 | COUPLING A 2-HALO-5-NITROBENZOIC ACID AND A 2-METHOXYPHENYL BORONIC ACID; CYCLIZING TO A NITROBENZOCOUMARIN; REDUCING TO THE AMINE; CONVERTING TO A COUMARINO(3,4-F)QUINOLINE; REDUCTION TO A 5H-CHROMENO(3,4-F)QUINOLINE | LIGAND PHARMACEUTICALS INCORPORATED | 2002-09-10 | — | — | US | disclosed |
| EP-0800519-A1 | STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS, INC. (US) | 1997-10-15 | — | — | EP | disclosed |
| WO-1996019458-A2 | STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 1996-06-27 | — | — | WO | disclosed |