Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 9/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7853762 | 0.92 | S1PR1 (0.47) | S1PR1PRMT5EGFRMPLMAPKAPK2 | |
| Hydrochloric Acid SCHEMBL7677790 | 0.85 | KMT2A (0.40) | S1PR1PRMT5EGFRMPLKIF11 | |
| SCHEMBL7676904 | 0.84 | SIRT1 (0.43) | MAPKAPK2 | |
| SCHEMBL7682184 | 0.81 | S1PR1 (0.47) | S1PR1MAPKAPK2 | |
| SCHEMBL7676958 | 0.81 | MAPKAPK2 (0.60) | PRMT5EGFRMAPKAPK2 | |
| SCHEMBL7843811 | 0.80 | MAPKAPK2 (0.63) | MAPKAPK2 | |
| SCHEMBL7852507 | 0.79 | MAPKAPK2 (0.45) | S1PR1MAPKAPK2 | |
| SCHEMBL7850754 | 0.79 | MAPKAPK2 (0.40) | MAPKAPK2 | |
| SCHEMBL7851653 | 0.78 | MAPKAPK2 (0.62) | MAPKAPK2 | |
| SCHEMBL7850944 | 0.78 | AR (0.43) | S1PR1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350757-B1 | Beta-carboline compounds | LES LABORATOIRES SERVIER (FR) | 2002-02-26 | — | — | US | disclosed |
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | disclosed |