Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CCNC | P24863 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | TFEB | P19484 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6561859 | 0.84 | CA1 (0.56) | PTPN1MAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL8534634 | 0.84 | MAPT (0.59) | PTPN1MAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL8534636 | 0.84 | MAPT (0.59) | PTPN1MAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL7455794 | 0.84 | CA1 (0.56) | PTPN1MAPTALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL2328371 | 0.80 | NFKB1 (0.50) | PTPN1MAPTLMNACCNCCDK8 | |
| SCHEMBL12425723 | 0.79 | HDAC8 (0.58) | MAPTALDH1A1TP53SMN1; SMN2MEN1 | |
| SCHEMBL815585 | 0.79 | MAPT (0.58) | MAPTALDH1A1SMN1; SMN2LMNANFKB1 | |
| SCHEMBL815583 | 0.79 | MAPT (0.58) | MAPTALDH1A1SMN1; SMN2LMNANFKB1 | |
| SCHEMBL29523356 | 0.78 | GSK3B (0.44) | MAPTALDH1A1TP53SMN1; SMN2GAA | |
| SCHEMBL20030390 | 0.77 | MAPT (0.40) | PTPN1MAPTALDH1A1TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6414013-B1 | KINASE INHIBITORS; ANTICANCER AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-07-02 | — | — | US | disclosed |