SCHEMBL7677780

SCHEMBL7677780

O=C(COC1=CCCCC1)Oc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
ALDH1A1 P00352 2/20 0.41
HPGD P15428 1/20 0.41
GAA P10253 2/20 0.40
KDM4E B2RXH2 1/20 0.39
POLB P06746 1/20 0.39
ALOX15 P16050 1/20 0.39
CYP19A1 P11511 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
LMNA P02545 1/20 0.37
PRSS1 P07477 1/20 0.37
PRSS2 P07478 1/20 0.37
PRSS3 P35030 1/20 0.37
PTGS2 P35354 1/20 0.36
CXCR1 P25024 1/20 0.36
CXCR2 P25025 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17363823 0.79 HDAC3 (0.32) ALDH1A1GAALMNA
SCHEMBL472137 0.76 HPGD (0.48) MEN1KMT2AALDH1A1HPGDCYP19A1
SCHEMBL472034 0.75 ALOX15 (0.65) MEN1KMT2AALDH1A1HPGDGAA
SCHEMBL28317930 0.74 KCNA3 (0.47) MEN1KMT2AALDH1A1
SCHEMBL1686063 0.74 ALDH1A1 (0.48) MEN1KMT2AALDH1A1HPGDGAA
SCHEMBL28408793 0.71 ALDH1A1 (0.43) KMT2AALDH1A1HPGDGAAKDM4E
SCHEMBL6353529 0.70 KMT2A (0.51) MEN1KMT2AALDH1A1GAAALOX15
SCHEMBL7311628 0.70 LTA4H (0.44)
SCHEMBL11437247 0.69 CYP19A1 (0.52) MEN1KMT2AALDH1A1HPGDGAA
SCHEMBL8878303 0.69 ALDH1A1 (0.31) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6376684-B1 CHEMICAL INTERMEDIATE FOR OXYBUTYNIN-TYPE COMPOUNDS SEPRACOR INC. 2002-04-23 US disclosed
EP-1127043-A1 STEREOSELECTIVE PROCESS FOR PREPARING (CYCLO)ALKYL PHENYLGLYCOLIC ACIDS Sepracor Inc. (US) 2001-08-29 EP disclosed
US-6180823-B1 CONDENSING SUBSTITUTED ACETALDEHYDE WITH ENANTIOMER OF MANDELIC ACID TO PROVIDE 5-PHENYL-1,3-DIOXOLAN-4-ONE, CONDENSING WITH CYCLOHEXANONE, DEHYDRATING PRODUCT, HYDROLYZING, REDUCING TO ALPHA-CYCLOHEXYLPHENYLGLYCOLIC ACID SEPRACOR INC. 2001-01-30 US disclosed
WO-2000027786-A1 STEREOSELECTIVE PROCESS FOR PREPARING (CYCLO)ALKYL PHENYLGLYCOLIC ACIDS SEPRACOR INC. (US) 2000-05-18 WO disclosed