SCHEMBL7678002

SCHEMBL7678002

Cc1cc(Cl)c(Sc2nnnn2CC(=O)C(CC(=O)O)NC(=O)SCc2ccccc2)c(Cl)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.37
TSHR P16473 3/20 0.37
HPGD P15428 1/20 0.37
CASP3 P42574 4/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
RECQL P46063 1/20 0.35
LMNA P02545 3/20 0.34
CTSA P10619 2/20 0.34
MAPK1 P28482 1/20 0.34
HTT P42858 1/20 0.34
KDM4E B2RXH2 2/20 0.34
CASP1 P29466 1/20 0.34
CASP7 P55210 1/20 0.34
CASP8 Q14790 1/20 0.34
PKM P14618 1/20 0.34
HSD17B10 Q99714 1/20 0.34
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7678219 0.92 ALDH1A1 (0.36) ALDH1A1TSHRHPGDCASP3CYP1A2
SCHEMBL7679379 0.91 ALDH1A1 (0.38) ALDH1A1TSHRHPGDCASP3CYP1A2
SCHEMBL7683738 0.91 ALDH1A1 (0.36) ALDH1A1TSHRHPGDCASP3CYP1A2
SCHEMBL7684582 0.89 ALDH1A1 (0.37) ALDH1A1TSHRHPGDCASP3CYP1A2
SCHEMBL7686252 0.87 CASP1 (0.46) CASP3CASP1
SCHEMBL7684926 0.86 CASP3 (0.37) ALDH1A1TSHRHPGDCASP3CYP1A2
SCHEMBL8171557 0.85 ALDH1A1 (0.35) ALDH1A1TSHRHPGDCASP3CYP1A2
Hydrochloric Acid SCHEMBL8176793 0.84 UBE2M (0.35) ALDH1A1TSHRHPGDCASP3CYP1A2
SCHEMBL7686947 0.84 TP53 (0.37) CASP3CTSACASP1CASP7CASP8
SCHEMBL7686151 0.84 ALDH1A1 (0.35) ALDH1A1TSHRHPGDCASP3CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136834-A TETRAZOLE PEPTIDES ONO PHARMACEUTICAL CO., LTD. (JP) 2000-10-24 US claimed
EP-0900791-A1 TETRAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 1999-03-10 EP claimed
US-6376484-B1 FOR PREVENTION AND/OR TREATMENT OF VARIOUS KINDS OF INFLAMMATORY DISEASE ONO PHARMACEUTICAL CO., LTD. (JP) 2002-04-23 US disclosed
US-6136834-A TETRAZOLE PEPTIDES ONO PHARMACEUTICAL CO., LTD. (JP) 2000-10-24 US disclosed
EP-0900791-A1 TETRAZOLE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 1999-03-10 EP disclosed