Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7673858 | 0.84 | RORC (0.31) | RORCNR1I3 | |
| SCHEMBL7672900 | 0.84 | RORC (0.31) | RORCNR1I3NPC1NFKB1RAB9A | |
| SCHEMBL7680558 | 0.83 | SMN1; SMN2 (0.37) | RORCMAPTNR1I3NPC1NFKB1 | |
| SCHEMBL7681595 | 0.72 | NR1I3 (0.37) | RORCMAPTNR1I3NPC1NFKB1 | |
| SCHEMBL7683114 | 0.72 | SMN1; SMN2 (0.38) | RORCMAPTNR1I3NPC1NFKB1 | |
| SCHEMBL27476598 | 0.70 | SMN1; SMN2 (0.39) | RORCMAPTNR1I3NPC1NFKB1 | |
| SCHEMBL7675073 | 0.69 | NPC1 (0.36) | MAPTNR1I3NPC1NFKB1RAB9A | |
| SCHEMBL7682758 | 0.65 | CYP11B2 (0.46) | MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7676130 | 0.64 | MAPT (0.40) | RORCMAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7676249 | 0.64 | HRH4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376490-B1 | STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES | PFIZER INC | 2002-04-23 | — | — | US | disclosed |
| EP-0885212-B1 | QUINOXALINEDIONES | PFIZER RES AND BR DEV COMPANY (IE) | 2001-11-14 | — | — | EP | disclosed |
| EP-0885212-A1 | QUINOXALINEDIONES | Pfizer Research and Development Company, N.V./S.A. (IE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032873-A1 | QUINOXALINEDIONES | PFIZER RESEARCH AND DEVELOPMENT COMPANY, N.V./S.A. (IE) | 1997-09-12 | — | — | WO | disclosed |