Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP17A1 | P05093 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27434418 | 0.84 | ALDH1A1 (0.43) | CYP11B2CYP11B1CYP19A1ALDH1A1HPGD | |
| SCHEMBL7676130 | 0.84 | MAPT (0.40) | HPGDNPC1PDGFRBPDGFRASQOR | |
| SCHEMBL7673152 | 0.77 | CYP11B2 (0.38) | CYP11B2CYP11B1CYP19A1ALDH1A1HPGD | |
| SCHEMBL7681550 | 0.76 | APLNR (0.41) | CYP11B2CYP11B1CYP19A1ALDH1A1HPGD | |
| SCHEMBL6678132 | 0.74 | OXTR (0.41) | CYP11B2CYP11B1CYP19A1ALDH1A1HPGD | |
| SCHEMBL7678750 | 0.74 | APLNR (0.39) | CYP11B2CYP11B1CYP19A1ALDH1A1HPGD | |
| SCHEMBL7680558 | 0.73 | SMN1; SMN2 (0.37) | ALDH1A1HPGDCYP3A4NPC1SQOR | |
| SCHEMBL7673869 | 0.73 | ALDH1A1 (0.43) | ALDH1A1HPGDCYP3A4NPC1MAPT | |
| SCHEMBL7682650 | 0.73 | APLNR (0.38) | CYP11B2CYP11B1CYP19A1ALDH1A1HPGD | |
| SCHEMBL7675073 | 0.72 | NPC1 (0.36) | HPGDCYP3A4NPC1SQORMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376490-B1 | STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES | PFIZER INC | 2002-04-23 | — | — | US | disclosed |
| EP-0885212-B1 | QUINOXALINEDIONES | PFIZER RES AND BR DEV COMPANY (IE) | 2001-11-14 | — | — | EP | disclosed |