Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1I3 | Q14994 | 2/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAPDH | P04406 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.32 |
| ▸ | TUBB | P07437 | 2/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27537113 | 0.86 | NPC1 (0.37) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL7680558 | 0.77 | SMN1; SMN2 (0.37) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL7681595 | 0.77 | NR1I3 (0.37) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL7683114 | 0.75 | SMN1; SMN2 (0.38) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL7682758 | 0.72 | CYP11B2 (0.46) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL7676130 | 0.71 | MAPT (0.40) | NPC1RAB9ASMN1; SMN2PTGESMAPT | |
| SCHEMBL7678666 | 0.69 | RORC (0.33) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL15958653 | 0.68 | KDM4E (0.49) | NPC1NFKB1RAB9ANFKB2RELA | |
| SCHEMBL7676206 | 0.66 | HRH4 (0.38) | NR1I3PTGESPGK1 | |
| SCHEMBL7681496 | 0.65 | SMN1; SMN2 (0.43) | SMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6376490-B1 | STRONG N-METHYL-D-ASPARATE RECEPTOR ANTAGONISTS; USEFUL IN TREATING STROKES, ISCHEMIA, AND CENTRAL NERVOUS SYSTEM INJURIES | PFIZER INC | 2002-04-23 | — | — | US | disclosed |
| EP-0885212-B1 | QUINOXALINEDIONES | PFIZER RES AND BR DEV COMPANY (IE) | 2001-11-14 | — | — | EP | disclosed |