Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.42 |
| ▸ | TSHR | P16473 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1321301 | 0.88 | HSD17B10 (0.38) | HSD17B10KDM4ETSHRHPGDALDH1A1 | |
| SCHEMBL6652713 | 0.77 | ALDH1A1 (0.40) | HSD17B10KDM4ETSHRHPGDALDH1A1 | |
| SCHEMBL3437947 | 0.76 | TLR4 (0.40) | HSD17B10KDM4ETSHRHPGDALDH1A1 | |
| SCHEMBL7817207 | 0.73 | HSD17B10 (0.65) | HSD17B10KDM4ETSHRHPGDALDH1A1 | |
| SCHEMBL2396347 | 0.72 | ALDH1A1 (0.42) | HSD17B10KDM4ETSHRHPGDALDH1A1 | |
| SCHEMBL31462136 | 0.71 | ALDH1A1 (0.44) | HSD17B10KDM4ETSHRHPGDALDH1A1 | |
| SCHEMBL3438533 | 0.69 | MAPT (0.50) | HSD17B10KDM4ETSHRHPGDALDH1A1 | |
| SCHEMBL2760986 | 0.68 | ALDH1A1 (0.46) | HSD17B10KDM4ETSHRHPGDALDH1A1 | |
| SCHEMBL9024433 | 0.68 | ALDH1A1 (0.42) | HSD17B10KDM4EHPGDALDH1A1MEN1 | |
| SCHEMBL14559235 | 0.68 | ALDH1A1 (0.42) | HSD17B10KDM4EHPGDALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6350749-B1 | SODIUM CHANNEL MODULATORS, ANTIARRHYTHMIA AND HYPOTENSIVE AGENTS; CARDIOVASCULAR DISORDERS, ANGINA PECTORIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-26 | — | — | US | disclosed |
| EP-1057812-A1 | AMINOGUANIDINE HYDRAZONE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2000-12-06 | — | — | EP | disclosed |
| EP-0261674-B1 | A CYCLOHEXANEDIONE DERIVATIVE AND A PROCESS FOR PRODUCING THE SAME | NIHON NOHYAKU CO., LTD. (JP) | 1991-06-12 | — | — | EP | disclosed |
| US-4863925-A | SUBSTITUTED | NIHON NOHYAKU CO., LTD. (JP) | 1989-09-05 | — | — | US | disclosed |
| EP-0261674-A1 | A cyclohexanedione derivative and a process for producing the same | NIHON NOHYAKU CO., LTD. (JP) | 1988-03-30 | — | — | EP | disclosed |