Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.47 |
| ▸ | KIF11 | P52732 | 11/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7678968 | 1.00 | SIRT1 (0.47) | SIRT1KIF11MAPKAPK2SIRT2SIRT3 | |
| SCHEMBL7683312 | 0.88 | MEN1 (0.46) | SIRT1KIF11SIRT2SIRT3 | |
| Hydrochloric Acid SCHEMBL7680915 | 0.88 | MEN1 (0.46) | SIRT1KIF11SIRT2SIRT3 | |
| SCHEMBL7853788 | 0.86 | SIRT1 (0.46) | SIRT1KIF11MAPKAPK2SIRT2SIRT3 | |
| SCHEMBL7855327 | 0.85 | KIF11 (0.47) | SIRT1KIF11MAPKAPK2SIRT2SIRT3 | |
| SCHEMBL7854615 | 0.85 | KIF11 (0.52) | SIRT1KIF11MAPKAPK2SIRT2SIRT3 | |
| SCHEMBL7853413 | 0.85 | MAPT (0.55) | SIRT1KIF11MAPKAPK2SIRT2SIRT3 | |
| SCHEMBL7843919 | 0.84 | ABCG2 (0.55) | SIRT1KIF11 | |
| SCHEMBL7855042 | 0.84 | ABCG2 (0.45) | SIRT1KIF11 | |
| SCHEMBL7847564 | 0.83 | SIRT1 (0.47) | SIRT1KIF11MAPKAPK2SIRT2SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | claimed |
| US-6350757-B1 | Beta-carboline compounds | LES LABORATOIRES SERVIER (FR) | 2002-02-26 | — | — | US | disclosed |
| EP-1070716-A1 | Beta-carboline derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2001-01-24 | — | — | EP | disclosed |